Endocrine Abstracts

Introduction: Pituitary adenomas are the most common cause of sellar masses. Several types of tumors may involve the sellar region, because of complex anatomy. They are classified according to size, function, immunohistochemical examination cell type of adenomas. Most of the pituitary adenomas without clinical function are gonadotropin-releasing adenomas on immunohistochemical examinations. They are usually seen as macroadenomas. They are often diagnosed with pituitary insuffi...

Introduction: There is a risk of hypercalcemia, nephrolithiasis, nephrocalsinosis, and renal failure in the treatment of hypoparathyroidism. We present a case who has an improvement of this complication after changing large doses of vitamin D to physiological doses of 1,25(OH)2D itself.Case report: A 50 years old man was admitted to hospital. He had idiopathic hypoparatyhroidism from the age of 24. He was using oral 1,25(OH)2D 0.25 ...

Thyroid eye disease (TED) represents the most frequent and important extrathyroidal manifestation of Graves' disease. Less commonly the eye changes may occur in euthyroid individuals without a preceding history of thyrotoxicosis, represents approximately 8-21% of TED cases. Patients with the rare combination of primary hypothyroidism and TED are predisposed to severe eye disease and atypical presentation of such patients may delay diagnosis and treatment . The primary importan...

Aim: Mitotane (o,p′-DDD) has been used to treat adrenocortical carcinoma (ACC) for several decades. Mitotane is often given in adjuvant setting after surgical resection of ACC and treatment usually lasts 2–3 years to reduce ACC recurrence. The use of mitotane is associated with multiple adverse effects. We herein report a case of marked hypercholesterolemia in a man receiving mitotane as adjuvant chemotherapy for ACC.Case: A 64-year-old man wa...

Aim: The aim of this study was to investigate the relationship between the clinical and laboratory findings of metabolic bone disease regarding the levels of osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa B ligand (RANKL) in the patients with diabetic nephropathy.Material and method: This study includes 61 type 2 diabetic patients and age-, sex-matched 20 healthy subjects. Diabetic patients were divided into three groups accordi...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Glucocorticoids decrease LDL degradation and expression of LDL receptor. Morever insulin resistance in glucocorticoid excess state may contribute to LDL oxidation changes. The aim of this study was to investigate, the LDL oxidation in glucocorticoid excess state and the effect of atorvastatin on LDL oxidation.<p class="...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Oestradiol and other oestrogens have been shown to be powerful antioxidants in vitro when they are added to ldl oxidation mixtures. Oestrogen deficiency states are increases LDL oxidation. The aim of this study is investigate the effect of growth hormone on LDL oxidation in estrogen deficiency.Materia...

Background: Proximal tubule dysfunction in Fanconi syndrome causes impaired reabsorbtion of amino acids, glucose, urate and phosphate, which leads to hypophosphatemic osteomalcia. Adefovir and tenofovir are two nucleoside reverse transcriptase inhibitors, which are used for treatment of patients with hepatitis B infection. Although these drugs are well tolerated with few side effects, patients may rarely suffer from drug-induced Fanconi syndrome and hypophosphatemic osteomalac...

Objective: Human growth hormone (hGH) stimulates bone formation and have been proposed as therapeutic agents for osteoporosis. We have examined the effects of hGH on femoral and vertebral bone strength in osteoporotic rats.Methods: Thirty-five Sprague-Dawley rats were assigned to study in three groups: (1) Normal rats (without ovariectomy and corticosteroid therapy) (2) Osteoporosis group: ovariectomized (OVX) or with glucocorticoid induced osteoporotic ...

Introduction: Langerhans cell histiocytosis (LHH) is an idiopathic, clonal, pleomorphic, neoplastic disorder characterized by the presence of atypical histiocytic cells which are locally or commonly seen in bone, lung, hypothalamus, liver, lymph nodes, mucocutaneous tissues with damaging them.Case: 58 year-old male patient applied to our clinic due to fatigue. On his physical examination, lymphadenopathy and hepatosplenomegaly were absent. In his history...